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Apoptosis/Tumor Suppressor Genes

Product Catalog# Quantity Unit Price Buy
APC (c-APC 28.9) Antibody DB109 0.100 mg/ml $275.00

Datasheet 

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Product Info
Background The adenomatous polyposis coli tumor suppressor gene is mutated (often deletion of the C-terminal portion of APC) in the inherited disease, familial adenomatous polyposis (FAP), and over 80% of colorectal cancers. APC is characterized by numerous polyps found throughout the entire colon. These polyps invariably progress to colon cancer in addition to other extracolonic manifestations (1-3). 
Form 100 g/ml of mouse monoclonal IgG1 in 1 ml PBS containing 0.1 % sodium azide and 0.2% gelatin. 
Immunogen Human APC carboxy terminal fusion with MBP 
Specificity Detects APC of human and mouse origin 
Use Western blotting, immunoprecipitation, and IHC (frozen sections), and immunofluorescence. Western blotting starting dilution: 1:200. Positive control: colon cell line HCT116 lysates. 
Storage Store this product at 4 C, do not freeze. The product is stable for one year from the date of shipment. 
References 1.Luk GD. 1995. Diagnosis and therapy of hereditary polyposis syndromes. Gastroenterologist 3:153-167.
2.Olschwag S, Laurent-Puig P, Melot T, Thuille B, and Thomas G. 1995. High resolution genetic map of the adenomatous polyposis coli gene (APC). Amer. J. Med. Gen. 56: 413-419.
3.Harach HR, Williams GT, and Williams ED. 1994. Familial adenomatous polyposis associated thyroid carcinoma: a distinct type of follicular cell neoplasm. Histopathology 25: 549-561. 

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Apoptosis/Tumor Suppressor Genes| Cell Adhesion| Cell Cycle| Controls| Fusion Protein/Epitope Tags| Growth Factors| Membrane Receptors
Protein Kinases| Secondary Antibodies| Signaling Intermediates| Transcription Regulation