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c-Myc (C10) Antibody DB061 0.200 mg/ml $190.00

Datasheet 
Datasheet 

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Product Info
Background The transcription factor c-Myc is a proto-oncogene that is at the focal point in cell cycle regulation, metabolism, apoptosis, differentiation, cell adhesion, and tumorigenesis (1-3). In normal cells the expression of c-Myc is tightly regulated but in human cancers c-Myc is frequently deregulated (2&3).c-Myc also plays a pivotal role in apoptosis, most notably its connections to the CD95/Fas death receptor pathway (1&4). These different biological responses to c-Myc are most likely the result of different overlapping subsets of c-Myc target genes (1). 
*Product Citations* 1.) Yakisich JS, Sandoval PY, Morrison TL, Kapler GM. 2006. TIF1 activates the intra-S-phase checkpoint response in the diploid micronucleus and amitotic polyploid macronucleus of Tetrahymena. Mol Biol Cell. Dec;17(12):5185-97.
2.) Schmauch C, Maniak M. 2008. Competition between targeting signals in hybrid proteins provides information on their relative in vivo affinities for subcellular compartments. Eur J Cell Biol. Feb;87(2):57-68. 
Origin c-Myc (C10) is provided as an affinity purified rabbit polyclonal antibody, raised against a synthetic peptide mapping near the carboxy terminal domain of human c-Myc. 
Product Details Each vial contains 200 g/ml rabbit polyclonal IgG c-Myc (C10) DB061, in 1 ml PBS containing 0.1 % sodium azide and 0.2% gelatin. 
Competition Studies A blocking peptide is also available, DB061P, for use in competition studies. Each vial contains 0.100 mg of peptide in 0.5 ml PBS with 0.1% sodium azide and 100 mg BSA. 
Form 200 g/ml rabbit polyclonal IgG in 1 ml PBS containing 0.1 % sodium azide and 0.2% gelatin. 
Immunogen synthetic peptide mapping near the carboxy terminal domain of human c-Myc. 
Specificity c-Myc (C10) reacts with c-Myc of human origin. Also recognizes the 9E10 c-Myc Tag. 
Use western blotting, immunopreciptation, and immunohistochemistry. Recommended starting dilution for western bloting 1:200. 
Storage Store this product at 4 C, do not freeze. The product is stable for one year from the date of shipment. 
References 1. Hoffman B, Amanullah A, Shafarenko M, Liebermann DA. 2002. The proto-oncogene c-myc in hematopoietic development and leukemogenesis. Oncogene 21(21): 3414-3421.
2. Boxer LM, Dang CV. 2001. Translocations involving c-myc and c-myc function. Oncogene 20(40):5595-5610.
3. Dang CV, Resar LM, Emison E, Kim S, Li Q, Prescott JE, Wonsey D, Zeller K. 1999. Function of the c-Myc oncogenic transcription factor. Exp Cell Res 253(1): 63-77.
4. Prendergast GC. 1999. Mechanisms of apoptosis by c-Myc. Oncogene 18(19):2967-2987.
 

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Apoptosis/Tumor Suppressor Genes| Cell Adhesion| Cell Cycle| Controls| Fusion Protein/Epitope Tags| Growth Factors| Membrane Receptors
Protein Kinases| Secondary Antibodies| Signaling Intermediates| Transcription Regulation