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beta-Catenin (C18) Antibody DB077 0.200 mg/ml $210.00

Datasheet 
Datasheet 

For technical service please call (800) 595 1994
Product Info
Background The multifunctional beta-catenin protein was originally identified through its association with the cadherin class of cell adhesion proteins (1&2). It was later found to be an integral part of signal transduction pathways and the best studied is the Wnt/beta-catenin pathway (3). Wnt signaling inhibits the degradation of beta-catenin and as a result beta-catenin becomes transcriptionally active (3-5). The deregulation of Wnt signaling leads to the accumulation of beta-catenin, allowing it to become transcriptionally active for a number of genes. Many of these genes are associated with cancer, such as colorectal cancer and melanomas (3&4). 
Origin beta-catenin (C18) is provided as an affinity purified rabbit polyclonal antibody, raised against a peptide mapping to the carboxy terminal domain of human beta-catenin. 
Product Details Each vial contains 200 µg/ml of affinity purified rabbit IgG, beta-catenin (C18) DB077, in 1 ml PBS containing 0.1 % sodium azide and 0.2% gelatin. 
Competition Studies A blocking peptide is also available, DB077P, for use in competition studies. Each vial contains 0.100 mg of peptide in 0.5 ml PBS with 0.1% sodium azide and 100 mg BSA. 
Form 200 µg/ml rabbit polyclonal IgG in 1 ml PBS containing 0.1 % sodium azide and 0.2% gelatin. 
Immunogen Synthetic peptide mapping to the carboxy terminal domain of human beta-catenin. 
Specificity beta-catenin (C18) is recommended to detect mouse, rat and human beta-catenin 
Use
Western blot anlaysis of beta-catenin expression in A431 whole cell lysates. 
Storage Store this product at 4º C, do not freeze. The product is stable for one year from the date of shipment. 
References 1. Hinck L, Nathke IS, Papkoff J, Nelson WJ. 1994. ?-catenin: a common target for the regulation of cell adhesion by Wnt-1 and Src signaling pathways. Trends Biochem Sci. 19(12):538-542.
2. Bullions LC, Levine AJ. 1998. The role of ?-catenin in cell adhesion, signal transduction, and cancer. Curr Opin Oncol. 10(1):81-87.
3. Moon RT, Bowerman B, Boutros M, Perrimon N. 2002. The promise and perils of Wnt signaling through ?-catenin. Science 296(5573):1644-1646.
4. Li H, Pamukcu R, Thompson WJ. 2002. ?-catenin signaling: therapeutic strategies in oncology. Cancer Biol Ther. (6):621-625.
5. Hecht A, Kemler R. 2000. Curbing the nuclear activities of ?-catenin. Control over Wnt target gene expression. EMBO 1(1):24-28.
 

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