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c-Myc (C10) Antibody DB061 0.200 mg/ml $210.00

Datasheet 
Datasheet 

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Product Info
Background The transcription factor c-Myc is a proto-oncogene that is at the focal point in cell cycle regulation, metabolism, apoptosis, differentiation, cell adhesion, and tumorigenesis (1-3). In normal cells the expression of c-Myc is tightly regulated but in human cancers c-Myc is frequently deregulated (2&3).c-Myc also plays a pivotal role in apoptosis, most notably its connections to the CD95/Fas death receptor pathway (1&4). These different biological responses to c-Myc are most likely the result of different overlapping subsets of c-Myc target genes (1). 
*Product Citations* 1.) Yakisich JS, Sandoval PY, Morrison TL, Kapler GM. 2006. TIF1 activates the intra-S-phase checkpoint response in the diploid micronucleus and amitotic polyploid macronucleus of Tetrahymena. Mol Biol Cell. Dec;17(12):5185-97.
2.) Schmauch C, Maniak M. 2008. Competition between targeting signals in hybrid proteins provides information on their relative in vivo affinities for subcellular compartments. Eur J Cell Biol. Feb;87(2):57-68. 
Origin c-Myc (C10) is provided as an affinity purified rabbit polyclonal antibody, raised against a synthetic peptide mapping near the carboxy terminal domain of human c-Myc. 
Product Details Each vial contains 200 µg/ml rabbit polyclonal IgG c-Myc (C10) DB061, in 1 ml PBS containing 0.1 % sodium azide and 0.2% gelatin. 
Competition Studies A blocking peptide is also available, DB061P, for use in competition studies. Each vial contains 0.100 mg of peptide in 0.5 ml PBS with 0.1% sodium azide and 100 mg BSA. 
Form 200 µg/ml rabbit polyclonal IgG in 1 ml PBS containing 0.1 % sodium azide and 0.2% gelatin. 
Immunogen synthetic peptide mapping near the carboxy terminal domain of human c-Myc. 
Specificity c-Myc (C10) reacts with c-Myc of human origin. Also recognizes the 9E10 c-Myc Tag. 
Use western blotting, immunopreciptation, and immunohistochemistry. Recommended starting dilution for western bloting 1:200. 
Storage Store this product at 4º C, do not freeze. The product is stable for one year from the date of shipment. 
References 1. Hoffman B, Amanullah A, Shafarenko M, Liebermann DA. 2002. The proto-oncogene c-myc in hematopoietic development and leukemogenesis. Oncogene 21(21): 3414-3421.
2. Boxer LM, Dang CV. 2001. Translocations involving c-myc and c-myc function. Oncogene 20(40):5595-5610.
3. Dang CV, Resar LM, Emison E, Kim S, Li Q, Prescott JE, Wonsey D, Zeller K. 1999. Function of the c-Myc oncogenic transcription factor. Exp Cell Res 253(1): 63-77.
4. Prendergast GC. 1999. Mechanisms of apoptosis by c-Myc. Oncogene 18(19):2967-2987.
 

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Apoptosis/Tumor Suppressor Genes| Cell Adhesion| Cell Cycle| Controls| Fusion Protein/Epitope Tags| Growth Factors| Membrane Receptors
Protein Kinases| Secondary Antibodies| Signaling Intermediates| Transcription Regulation